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Meeting Registration Grants You Access to ALL Zoom Sessions

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Click on the links below to go directly to that day's program information 

Wednesday   |   Thursday   |   Friday  

Wednesday, September 28, 2022
 

Welcome to the PISA 2022 Young Investigators Virtual Meeting
12:15 PM - 12:30 PM (ET)
Vik Meadows, PhD, Chair
Rutgers University

Debjyoti Kundu, MS
SESSION 1 - Liver Pathobiology
Session Co-Chairs: Debjyoti Kundu, MS and Rulaiha Taylor, BS
12:30 PM - 2:45 PM (ET)
Rulaiha Taylor, BS

12:30 PM -
1:15 PM (ET)

Nelson Fausto

Nelson Fausto Memorial Keynote Lecture

Deciphering the Role of the Unfolded Protein Response in Hepatic Fibrogenesis

Jessica L. Maiers, PhD, Indiana University School of Medicine

Jessica L. Maiers, PhD

Young Investigator Short Talks

  • 1:15 PM - 1:30 PM (ET)
    Abstract #22 - Autophagy Regulates Hepatic Acetylome
    Kamal Baral, Niani Bailey, Arissa Mercer, Nickol Wahby, Gang Liu, Xiao-Ming Yin, and Bilon Khambu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
  • 1:30 PM - 1:45 PM (ET)
    Abstract #23 - MDR1 as a Potential Therapeutic Target for Progressive Familial Intrahepatic Cholestasis Type II in Children
    Makenzie Fourman1,2, Jillian Ellis1, Hannah Nartker1, and Chunyue Yin1,3
    1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH, and 3Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
  • 1:45 PM - 2:00 PM (ET)
    Abstract #24 - Targeted β-catenin Overexpression Mediates Biliary Repair in Murine Model of Intrahepatic Cholestasis
    Chhavi Goel1, Qin Li2, Pamela Cornuet1, and Kari Nejak-Bowen1,3
    1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, and 3Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • 2:00 PM - 2:15 PM (ET)
    Abstract #25 - Cromolyn Sodium Ameliorates Mast Cell(MC)-mediated Hepatic Damage in a Murine Model of Non-alcoholic Steatohepatitis (NASH)
    Debjyoti Kundu1, Tianhao Zhou1, Lindsey Kennedy1,2, Konstantina Kyritsi1, Gianfranco Alpini1,2, and Heather Francis1,2
    1Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 2Richard L. Roudebush V.A Medical Center, Indianapolis, IN
  • 2:15 PM - 2:30 PM (ET)
    Abstract #26 - Nrf2 Negatively Regulates CMA to Rescue Macroautophagy Deficiency Induced Liver Dysfunction
    Gang Liu and Xiao-Ming Yin
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
  • 2:30 PM - 2:45 PM (ET)
    Abstract #28 - ASBT Vivo-Morpholino Reduces Hepatic Inflammation and Fibrosis and Alters Bile Acid Composition In Cholestatic Mice
    Vik Meadows1, Corinn Marakovits1, Debjyoti Kundu1, Lindsey Kennedy1,2, Tianhao Zhou1, Lixian Chen1, Ludovica Ceci1, Konstantina Kyritsi1, Nan Wu1, Burcin Ekser3, Gianfranco Alpini1,2, and Heather Francis1,2
    1Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 2Richard L. Roudebush V.A Medical Center, Indianapolis, IN, and 3Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
Michele Alves, PhD
Session 2 - Neuropathology and Ocular Pathology
Session Co-Chairs: Michele Alves, PhD and Zhengping Hu, MD, PhD
3:15 PM - 5:30 PM (ET)
Zhengping Hu, MD, PhD

3:15 PM -
4:00 PM (ET)

Ruth Kirschstein

Ruth Kirschstein Memorial Keynote Lecture

Neuropathology of Autonomic Dysfunction

Jose J. Otero, MD, PhD, The Ohio State University

Jose J. Otero, MD, PhD

Young Investigator Short Talks

  • 4:00 PM - 4:15 PM (ET)
    Abstract #31 - 2-(4-aminophenyl)benzothiazole Derivatives Modulate Transthyretin Aggregation
    Vivek Grandhe, Kendall B. E. Moore, A. Prasanth Saraswati, and Jessica S. Fortin
    Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN
  • 4:15 PM - 4:30 PM (ET)
    Abstract #32 - A Pathologic Triangle: Herpesviruses, Autophagy Genes, and Alzheimer’s Disease
    Mohsen Ranjbar, Amir R. Nafchi, Mona Esmaeili, Orrin B. Myers, and Elaine L. Bearer
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM
  • 4:30 PM - 4:45 PM (ET)
    Abstract #33 - Reconfiguration of Adult Brain Responses to Threat After Early Life Adversity
    Taylor W. Uselman1, Russell E. Jacobs2, and Elaine L. Bearer1,3
    1Department of Pathology, Univ. of New Mexico Health Sciences Center, Albuquerque, NM, 2Zilkha Neurogenetic Institute, USC Keck School of Medicine, Los Angeles, CA, and 3Beckman Institute, California Institute of Technology, Pasadena, CA
  • 4:45 PM - 5:00 PM (ET)
    Abstract #34 - Mitochondrial Transplantation as a Novel Inducer of Retinal Pigment Epithelium Epithelial-Mesenchymal-Transition and Fibrosis
    Erik R. Butcher1, Scott I. Frank1,3, Magali Saint-Geniez1,2, Leo A. Kim1,2, and Daisy Y. Shu1,2
    1Schepens Eye Research Institute of Mass Eye and Ear, 2Department of Ophthalmology, Harvard Medical School, Boston, MA, and 3Boston College, Boston, MA
  • 5:00 PM - 5:15 PM (ET)
    Abstract #35 - Protective Role of Resveratrol Against TNF-induced Inflammation and Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells
    Tessa C. Fitch1, Scott I. Frank1,3, Magali Saint-Geniez1,2, Leo A. Kim1,2, and Daisy Y. Shu1,2
    1Schepens Eye Research Institute of Mass Eye and Ear, 2Department of Ophthalmology, Harvard Medical School, Boston, MA, and 3Boston College, Boston, MA
  • 5:15 PM - 5:30 PM (ET)
    Abstract #36 - Endomucin Knockout Mice Show Delayed Retinal Vascular Development and Reduced Neovascularization in Oxygen-induced Retinopathy
    Zhengping Hu1,2, Issahy Cano1,2, Magali Saint-Geniez1,2, Yin Shan Eric Ng1,2, and Patricia A. D’Amore1,2,3
    1Schepens Eye Research Institute of Massachusetts Eye and Ear, 2Departments of Ophthalmology, and 3Pathology, Harvard Medical School, Boston, MA

 

Thursday, September 29, 2022

Career Development Session - How to Obtain Funding
10:00 AM - 11:00 AM (ET)

Description: Interested in applying to an F31, pilot/society grant, or travel award? Join us as we decode what it takes to get grants! We will cover topics relevant to the application process including how to keep up your online profile and best practices in grant applications.

Moderator: Corinn Marakovits, Indiana University School of Medicine
Panelists: George Perry, PhD, The University of Texas at San Antonio
Elaine Bearer, MD, PhD, University of New Mexico Health Science Center
Daisy Shu, PhD, Schepens Eye Research Institute
Staci Weaver, PhD Candidate, Indiana University School of Medicine

REGISTER

Joud Mulla, BS, MS
Session 3 - Infectious Disease & Gene Expression
Session Co-Chairs: Joud Mulla, BS, MS and Alfredo Ornelas Sanchez, PhD
12:30 PM - 2:45 PM (ET)
Alfredo Ornelas Sanchez, PhD

12:30 PM -
1:15 PM (ET)

Robert E. Stowell

Robert E. Stowell Memorial Keynote Lecture

EphB/EphrinB Signaling in Pathological Organ Fibrosis

Patrice Mimche, PhD, University of Utah

Patrice Mimche, PhD

Young Investigator Short Talks

  • 1:15 PM - 1:30 PM (ET)
    Abstract #13 - Loss of Myo5b Results in Improper Delivery of the Intermicrovillar Adhesion Complex Components
    Sarah A. Dooley1, Jessica R. Digrazia1, Kristen Engevik2, Rachel Stubler3, Evan Krystofiak4, Izumi Kaji5, and Amy C. Engevik1
    1Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 2Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 3Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, 4Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, and 5Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN
  • 1:30 PM - 1:45 PM (ET)
    Abstract #18 - Inhibition of LPS-mediated Inflammation by Intravenous Administration of a Cationic Antimicrobial Peptide in Mice
    Justin Curtis1, Joud Mulla1, Zachary Secunda1, Bashar AlMatour1, Berthony Deslouches2, and Melanie J. Scott1
    1Department of Surgery, University of Pittsburgh, Pittsburgh, PA, and 2Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA
  • 1:45 PM - 2:00 PM (ET)
    Abstract #19 - Interaction Between Zika Virus and a Mosquito Axl-like Protein
    Jacob Donahue and Catherine Miller
    Department of Biological Sciences, University of Southern Maine, Portland, ME
  • 2:00 PM - 2:15 PM (ET)
    Abstract #30 - Platelet-rich Fibrin (PRF) Accelerates the Healing of Achilles Tendon Defect by Promoting the Proliferation and Activation of Tenocytes via FGFR/AKT and TGF-?/SMAD3 Signaling
    Yoshiyuki Senga, Akinobu Nishimura, Daisuke Katoh, and Akihiro Sudo
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
  • 2:15 PM - 2:30 PM (ET)
    Abstract #27 - Bulk RNA Seq Identifies Activation of Oxidative Stress Regulating Glucose/lipid Metabolism as Potential Mechanism of Increased Glucose Sensitivity Under Conditional Knockdown of HMGB1 in a Type-2 Diabetes Model
    Zeyu Liu1, Silvia Liu2,3, Jian-Hua Luo2,3, Yan-Ping Yu2,3, Baoguo Ren2,3, Gowtham Annarapu4, David Akinbode1, and Roberto Ivan Mota Alvidrez1,2,3,4,5
    1Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 3Pittsburgh Liver Research Center Institute, University of Pittsburgh, Pittsburgh, PA, 4Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, and 5McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA
  • 2:30 PM - 2:45 PM (ET)
    Abstract #29 - MicroRNA Drivers for Regenerative Capacity in Liver Transplantation
    Ankita Srivastava, Benjamin K. Barnhart, Alexandra Manchel, Jan B. Hoek, and Rajanikanth Vadigepalli
    Daniel Baugh Institute for Functional Genomics/Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA
2:45 PM -
3:15 PM (ET)
COFFEE BREAK
Janiece Glover, MS, BS
Session 4 - Cancer Pathobiology
Session Co-Chairs: Janiece Glover, MS, BS and Maryknoll Palisoc, BS, MS
3:15PM - 5:30 PM (ET)
Maryknoll Palisoc, BS, MS

3:15 PM -
4:00 PM (ET)

Henry C. Pitot

Henry C. Pitot Memorial Keynote Lecture

Mesothelial Cell-Derived Antigen-Presenting Cancer-Associated Fibroblasts in Pancreatic Cancer

Huocong Huang, MD, PhD, UT Southwestern

Huocong Huang, MD, PhD

Young Investigator Short Talks

  • 4:00 PM - 4:15 PM (ET)
    Abstract #1 - Subcellular Localization of Novel Fluorescent Epidermal Growth Factor Receptor (EGFR) and Hepatocyte Growth Factor Receptor (MET) Targeted Inhibitors in Cancer Cells
    Caterina Facchin, Alaa Baryyan, and Bertrand Jean-Claude
    Department of Medicine, Research Institute of McGill University Health Center, McGill University, Montreal, Quebec, Canada
  • 4:15 PM - 4:30 PM (ET)
    Abstract #2 - Targeting Nutrition Via Bioactive Lipids Enhances Immunotherapy in Cancer
    Abigail Kelly1,2, Franciele C. Kipper1,2, Eva Rothenberger1,2, Madeline Duncan1,2, Weicang Wang3,4, Sung Hee Hwang3,4, Bruce D. Hammock3,4, and Dipak Panigrahy1,2
    1Department of Pathology and 2Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Department of Entomology/Nematology, University of California at Davis, Davis, CA, and 4UCD Comprehensive Cancer Center, University of California at Davis, Davis, CA
  • 4:30 PM - 4:45 PM (ET)
    Abstract #3 - Oral Pathogens Regulate Epithelial Cell Behavior Though the Adherens Junction-associated RNAi Machinery
    Christina Kingsley, Joyce Nair-Menon, Melinda Engevik, and Antonis Kourtidis
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC
  • 4:45 PM - 5:00 PM (ET)
    Abstract #4 - PIK3CA and cMYC Promote the Expansion of Distinct Ras-initiated, Long-lived Premalignant Clones in a Multistage Murine Breast Cancer Model
    Maryknoll Linscott, Jerry Ren, Shelley Gestl, and Edward Gunther
    Gittlen Laboratories for Cancer Research, Penn State College of Medicine, Hummelstown, PA
  • 5:00 PM - 5:15 PM (ET)
    Abstract #5 - The Roles of the Histone Demethylase KDM5A in Breast Cancer and Senescence
    Thomas J. McCabe1, Sabine Lang1, Keisuke Aoshima2, Lizhen Wu3, Jian Cao4, and Qin Yan1,5
    1Department of Pathology, Yale School of Medicine, New Haven, CT, 2Laboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, 3Department of Immunobiology, Yale School of Medicine, New Haven, CT, 4Division of Medical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, 5Yale Cancer Center, Yale School of Medicine, New Haven, CT
  • 5:15 PM - 5:30 PM (ET)
    Abstract #6 - Eicosanoid Regulation of Bladder Cancer
    Eva Rothenberger1,2, Weicang Wang3, Franciele C. Kipper1,2, Abigail Kelly1,2, Sung Hee Hwang3, Madeline Duncan1,2, Diane R. Bielenberg4, Bruce D. Hammock3, and Dipak Panigrahy1,2
    1Department of Pathology and 2Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Department of Entomology/Comprehensive Cancer Center, University of California at Davis, Davis, CA, and 4Vascular Biology Program, Boston Children’s Hospital, Boston, MA

 

Friday, September 30, 2022

Career Development Session - PhD to Postdoc Transition
10:00 AM - 11:00 AM (ET)

Description: You’re nearly done with your PhD… Now what? Join us as we explore the next steps for PhDs including career planning, funding, and find the right mentor for you. Come ask your questions to our panel of post docs interested in academic, industry, and administrative careers.

Moderators: Janiece Glover, MS, BS and Vik Meadows, PhD
Panelists: Daenique Jengelley, PhD, Indiana University
Lauren Walker, PhD, Rutgers University
Nathaniel Lartey, PhD, University of Michigan
Kristen Engevik, PhD, Baylor College of Medicine

REGISTER

Danielle Kozlosky, BS
Session 5 - Cardiovascular and Pulmonary Disease
Session Co-Chairs: Danielle Kozlosky, BS and Cristina Espinosa-Diez, PhD
12:00 PM - 2:45 PM (ET)
Cristina Espinosa-Diez, PhD

12:00 PM -
12:45 PM (ET)

Tucker Collins

Tucker Collins Memorial Keynote Lecture

Smooth Muscle Cells and Platelets: A Toxic Yet Crucial Relationship in Diabetic Vasculopathy

Roberto Mota-Alvidrez, MD, University of Pittsburgh Medical Center

Roberto Mota-Alvidrez, MD

Young Investigator Short Talks

 
  • 12:45 PM - 1:00 PM (ET)
    Abstract #8 - PTSD-Induced Alterations of Cardiac Homeostasis
    Alexa Corker1, Miguel Troncoso2, Philip Broughton1, Sara Sidles2,3, Ryan Kelly2,3, Amanda LaRue2,3, and Kristine Y. DeLeon-Pennell1,2
    1Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, 2Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, 3Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC
  • 1:00 PM - 1:15 PM (ET)

    Abstract #9 - Effects of Obesity on Angiogenesis and Regenerative Lung Growth
    Tendai Hunyenyiwa1,2, Priscilla Kyi1,2, Kienna Matus1, Tadanori Mammoto1,3, and Akiko Mammoto1,2
    1Department of Pediatrics, 2Department of Cell Biology, Neurobiology and Anatomy, and 3Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI

  • 1:15 PM - 1:30 PM (ET)

    Abstract #10 - Endothelial Senescence Mediates Hypoxia-induced Vascular Remodeling in the Lung Through TWIST1 Signaling
    Priscilla Kyi1,2, Tendai Hunyenyiwa1,2, Kienna Matus1, Tadanori Mammoto1,3, and Akiko Mammoto1,2
    1Department of Pediatrics, 2Department of Cell Biology, Neurobiology and Anatomy, and 3Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI

  • 1:30 PM - 1:45 PM (ET)
    Abstract #11 - The Effect of Caspase-11 in Trauma-Induced Coagulopathy (TIC)
    Joud Mulla, Nijmeh Alsaadi, Zachary Secunday, Rohan Katti, Justin Curtis, Matthew D. Neal, and Melanie J. Scott
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA
  • 1:45 PM - 2:00 PM (ET)
    Abstract #12 - Interstitial Fibrosis and Macrophages Persist in the Myocardium Following Removal of Left Ventricular Pressure Overload
    Lily S. Neff1, An O. Van Laer1, Catalin F. Baicu1, Michael R. Zile1,2, and Amy D. Bradshaw1,2
    1Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, 2The Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina
2:45 PM -
3:15 PM (ET)
COFFEE BREAK
AdePeju Oshodi, BS
Session 6 - Gastrointestinal Pathobiology
Session Co-Chairs: AdePeju Oshodi, BS and Sophia Blessinger
3:15 PM - 5:30 PM (ET)
Sophia Blessinger

3:15 PM -
4:00 PM (ET)

Ramzi S. Cotran

Ramzi S. Cotran Memorial Keynote Lecture

Emerging Neutrophil Functions in Gut Inflammation and Colon Cancer

Ronen Sumagin, PhD, Northwestern University

Ronen Sumagin, PhD

Young Investigator Short Talks

  • 4:00 PM - 4:15 PM (ET)
    Abstract #14 - Rotavirus Infection Elicits Host Responses via P2Y1 Purinergic Signaling
    Kristen Engevik1, Takahiro Kawagishi2, John Thomas Gebert1, Francesca Scribano1, Jacob Perry1, Harry Greenberg2, and Joseph Hyser1
    1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, and 2Department of Medicine, Gastroenterology and Hepatology, Stanford University, Stanford, CA
  • 4:15 PM - 4:30 PM (ET)
    Abstract #15 - Acinetobacter calcoaceticus is Adept at Colonizing the Gastrointestinal Tract and Stimulating Inflammation
    Janiece S. Glover, Brittney D. Browning, Taylor D. Ticer, Amy C. Engevik, and Melinda A. Engevik
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC
  • 4:30 PM - 4:45 PM (ET)
    Abstract #16 - Restoration of Colonic Barrier Protein Expression following Lipopolysaccharide and Cytokine-Induced Inflammation in Human Colon Organoids
    Daniyal M. Nadeem, Isabelle Harber, Shannon D. McClintock, James Varani, and Muhammad Nadeem Aslam
    Department of Pathology, University of Michigan, Ann Arbor, MI
  • 4:45 PM - 5:00 PM (ET)
    Abstract #17 - Small Intestinal Responses to Giardia muris Infection in Tuft Cell-Deficient Mice
    Olivia S. Sosnowski1, Thibault Allain1, Elena Fekete1, Derek M. McKay2, and Andre G. Buret1
    1Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada 2Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  • 5:00 PM - 5:15 PM (ET)
    Abstract #20 - Mechanistic Insights into Macrophage Regulation of Neutrophil Transendothelial Migration in Inflamed Mucosa
    Xingsheng Ren, Jessica Mae Urbanczyk, and Ronen Sumagin
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
  • 5:15 PM - 5:30 PM (ET)
    Abstract #21 - Klebsiella pneumoniae Isolates From Patients With Inflammatory Bowel Disease Influences Clostridioides difficile Pathogenesis
    Taylor D. Ticer1, Janiece S. Glover2, Suzanne Devkota3, Joseph Zackular4, and Melinda A. Engevik1,2
    1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 2Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 3Division of Gastroenterology, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, and 4Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Awards Presentations
William B. Coleman, PhD, ASIP Executive Officer

Closing Remarks
William Muller, MD, PhD, ASIP President